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GSK Scientists Close To Eradicating Gonorrhea Infection

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Gonorrhea, a well-known Sexually Transmitted Infection (STI) often referred to as “The Gentleman’s Disease,” has a long-standing history and global prevalence.

 

However, scientists from GlaxoSmithKline (GSK) have expressed hope that the disease could soon be eradicated.

 

In recent years, the rise of drug-resistant strains of the bacteria responsible for gonorrhea, known as Neisseria gonorrhoeae, has significantly complicated its treatment with conventional medications.

 

As a result, the disease has become increasingly difficult to cure, nearing a state of near incurability.

 

The issue of antibiotic resistance in the treatment of gonorrhea has raised concerns due to the fact that all bacteria associated with the infection have developed resistance to at least one commonly used antibiotic.

 

Ceftriaxone, an intravenously administered medication, is currently in high demand but also faces increasing resistance.

 

While a legal vaccine for gonorrhea is not currently available, researchers have now set their sights on the potential of an injectable vaccine, which could offer a treatment option.

 

The investigational vaccine has successfully completed phase I studies, demonstrating its safety for human use, and is currently progressing through phase II trials.

 

The anticipated timeline suggests that final testing for the vaccine could commence as early as 2026, potentially opening up a new avenue for combating gonorrhea.

 

The US Food and Drug Administration (FDA) has taken proactive measures to expedite the development of an experimental vaccine aimed at eliminating the threat of gonorrhea.

 

This initiative is expected to accelerate the approval process and facilitate the swift dissemination of the vaccine among the general population.

 

In a comprehensive study, phase II trials involved 750 participants from eight countries, including the US, UK, France, and Spain. These individuals, aged between 18 and 50, were specifically selected due to their higher risk of contracting gonorrhea.

 

The phase II trials commenced in November 2022, and by March 2025, the results of this phase are anticipated to be available. Subsequently, phase III trials will commence, marking another significant step towards the potential availability of the vaccine.

 

Patients receive two doses of the vaccine by injection into the muscle in order to produce immunity. The vaccine’s mechanism of action is unknown, but researchers note that similar vaccines have been created in the past that employ antigens from bacterial surfaces to elicit an immune response.

 

The FDA’s decision to provide our novel vaccine candidate against Neisseria gonorrhoeae illness Fast Track designation is something we applaud, according to Phil Dormitzer, the global head of vaccine development at GSK.

 

The global prevalence of gonorrhea poses a significant threat to sexual and reproductive health worldwide. With its high and increasing incidence, the need for effective prevention measures is paramount.

 

The prospect of a vaccine holds great promise in potentially safeguarding millions of individuals from the severe health consequences associated with this infection caused by a bacterium categorized by the World Health Organization as a “high priority” pathogen.

 

Gonorrhea can easily spread from one person to another through vaginal contact with an infected partner. Additionally, there is a risk of perinatal transmission from mother to baby during childbirth.

 

However, it is worth noting that men face a considerable 20 percent chance of contracting the disease through sexual activity. This emphasizes the importance of safe sexual practices and raises awareness about the risks associated with gonorrhea transmission.

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Health

25 Health Benefits Of Bitter Leaf

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Bitter leaf, also known as Vernonia amygdalina, has many health benefits.

It is being used in Africa and Asia for a long time to treat sickness.

Though it tastes bitter, that’s what makes it good for you. You can consume bitter leaf in different forms like juice or extract.

Studies have found that bitter leaf has good things like alkaloids and flavonoids. These can help with things like fighting inflammation, stopping bacteria, and even fighting cancer. People have used it for a long time to help with stomach problems, fevers, and liver issues.

In Africa, people often use bitter leaf in their traditional medicine, calling it “ewuro.” Tests have shown it really does have medicinal value. It’s becoming more popular worldwide. Bitter leaf also has antioxidants that protect your body from damage and help fight diseases.

One big benefit is that it helps with inflammation, which can cause many health problems. Bitter leaf has a compound called vernodalin that fights inflammation. It’s also good at fighting infections caused by bacteria and viruses.

Here are 25 health benefits of bitter leaf, and bitter leaf juice along with the constituents that provide each benefit:

1. Boosts Immune System: Bitter leaf is rich in antioxidants and other nutrients such as vitamin C and E which help to boost the immune system and protect the body from infections.

2. Helps With Weight Loss: Bitter leaf contains flavonoids that can help to stimulate the breakdown of fat, which makes it a great addition to a weight loss regimen.

3. Reduces Inflammation: The anti-inflammatory properties of bitter leaf can help to reduce inflammation in the body and relieve pain caused by conditions such as arthritis.

4. Treats Malaria: Bitter leaf contains a compound called vernodalin, which has been shown to be effective against the malaria parasite.

5. Regulates Blood Sugar: The antioxidants in bitter leaf can help to regulate blood sugar levels, making it a great natural remedy for people with diabetes.

6. Lowers Blood Pressure: Bitter leaf contains compounds that can help to relax blood vessels and lower blood pressure, making it a great addition to a heart-healthy diet.

7. Improves Digestion:
Bitter leaf can help to improve digestion by stimulating the production of digestive enzymes.

8. Treats Skin Infections: Bitter leaf has antimicrobial properties that can help to treat skin infections and prevent the growth of harmful bacteria. This is one of the popular health benefits of bitter leaf.

9. Fights Against Cancer:
Bitter leaf contains a compound called vernonolide that has been shown to have anticancer properties.

10. Boosts Liver Health: Bitter leaf can help to protect the liver from damage and improve liver function.

11. Treats Respiratory Infections: Bitter leaf has been used for centuries to treat respiratory infections such as bronchitis and pneumonia.

12. Treats Fever: Bitter leaf has antipyretic properties, which means it can help to reduce fever. This is one of the essential health benefits of bitter leaf.

13. Reduces Anxiety: Bitter leaf has a calming effect on the body and can help to reduce anxiety and stress.

14. Improves Cognitive Function: Bitter leaf contains antioxidants that can help to protect the brain from damage and improve cognitive function.

15. Promotes Wound Healing: The antimicrobial properties of bitter leaf can help to promote wound healing and prevent infection.

16. Treats Sore Throat:
Bitter leaf can help to soothe a sore throat and relieve coughing.

17. Fights Against Fungal Infections: Bitter leaf has antifungal properties that can help to treat fungal infections such as ringworm.

18. Boosts Fertility: Bitter leaf has been used for centuries to improve fertility in both men and women.

19. Treats Stomach Ulcers: Bitter leaf has been shown to be effective in treating stomach ulcers.

20. Lowers Cholesterol: Bitter leaf can help to lower cholesterol levels and reduce the risk of heart disease.

21. Promotes Healthy Eyes: Bitter leaf contains antioxidants that can help to protect the eyes from damage and improve vision.

22. Treats Urinary Tract Infections:
Bitter leaf has been used to treat urinary tract infections for centuries.

23. Reduces Menstrual Pain: Bitter leaf can help to reduce menstrual pain and regulate menstrual cycles.

24. Treats Insomnia: Bitter leaf can help to promote relaxation and treat insomnia.

25. Improves Skin Health: Bitter leaf contains vitamins and minerals that can help to improve skin health and reduce the appearance of fine lines and wrinkles.

Bitter leaf has many good things for your health. It has different helpful stuff like alkaloids, flavonoids, terpenes, and phenolic acids. These are what make bitter leaf good for you. Bitter melon leaf, bitter gourd leaf, ampalaya leaf, and vernonia amygdalina leaf all have benefits.

Bitter leaf can also help control blood sugar, which is great for people with diabetes. It also fights inflammation, fungus, and bacteria, which can keep you from getting sick.

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Health

More Women Living With HIV In Nigeria – NACA

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More Women Living With HIV In Nigeria, Reveals NACA

The National Agency for the Control of AIDS (NACA) has highlighted a worrisome trend in Nigeria, with Director General Dr Gambo Aliyu underscoring that more women than men are living with HIV in the country.

Dr Aliyu revealed that young Nigerian women were particularly vulnerable, being three times more likely to live with HIV compared to men in the same age bracket.

He categorically stated that six out of every ten individuals living with HIV in Nigeria were females.

In a press statement released on Tuesday to mark the upcoming International Women’s Day, Dr Aliyu emphasised the importance of empowering Nigerian women. He noted that this year’s theme, ‘Invest in Women: Accelerate Progress,’ aligns with NACA’s commitment to advancing gender equality and addressing the unique challenges faced by women living with HIV/AIDS.

Dr Aliyu stressed that investing in women is not just a financial commitment but also a catalyst for sustainable progress in society. By empowering women, he explained, positive transformations can occur within families, communities, and the nation as a whole.

In light of the International Women’s Day, NACA reaffirmed its dedication to empowering women and girls in the fight against HIV/AIDS. Dr Aliyu highlighted the agency’s ongoing efforts to promote inclusive policies, ensure access to comprehensive healthcare, and provide education to empower women to make informed decisions about their sexual and reproductive health.

Dr Aliyu expressed gratitude to individuals, organisations, and partners contributing to the advancement of women’s rights and the global HIV/AIDS response. He urged continued collaboration towards a future where every woman can live free from the burden of HIV/AIDS.

According to NACA, an estimated 1.8 million people are living with HIV in Nigeria, with approximately 1.63 million already receiving Antiretroviral Therapy, a life-saving medication.

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Health

Bello Grants 100% Hazard Allowance To Kogi Health Workers

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Kogi State Governor, Yahaya Bello, has taken a significant step by approving a 100% hazard allowance for medical doctors and healthcare professionals in the state.

The decision, aimed at boosting their morale, was disclosed during a courtesy visit by pioneer medical students from Prince Abubakar Audu University, Anyigba, and the Nigerian Medical Association (NMA) leadership at the Government House in Lokoja on Wednesday.

Recall that Governor Yahaya Bello’s administration inherited accreditation challenges for the pioneer set of medical students from the previous government.

In response, the governor placed these affected students on scholarship at various tertiary institutions nationwide, ensuring they could pursue their Bachelor of Medicine and Bachelor of Surgery (MBBS) degrees without hindrance.

Accompanied by their parents and the Abubakar Audu University’s management, including Vice Chancellor Prof. Marietu Ohunene-Tenuche, the students who completed their MBBS extended gratitude during the courtesy visit.

Prof. Ohunene-Tenuche specifically thanked Governor Yahaya Bello for his crucial financial support towards their education and acknowledged his significant investments in the state’s education sector.

Dr. Olusola Baoku, Chairman of the NMA, Kogi chapter, commended Governor Bello for significant advancements in the state’s health sector.

He praised Kogi as one of the seven states in the federation addressing hazard allowances, with a 50% payment for medical doctors.

Dr. Baoku also applauded the Bello administration for enhancing medical infrastructure, stating, “It’s clear now that Kogi is ready to establish and run a medical college.”

In response, Governor Bello affirmed his dedication to advancing healthcare, expressing a commitment to utilizing the state’s resources and policies for the training of medical professionals both within and outside Kogi State.

He clarified that this initiative aimed to address the manpower gap resulting from the “Japa Syndrome” prevalent in the country.

Governor Bello reiterated his administration’s commitment to fostering a conducive working environment for professionals within the state.

He further declared that the 100% hazard allowance for medical doctors and health workers in Kogi State would be implemented immediately.

Accompanied by governor-elect Usman Ododo, Bello assured ongoing enhancements across all economic sectors in Kogi, emphasizing a focus on improving healthcare delivery.

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