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GSK Scientists Close To Eradicating Gonorrhea Infection

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Gonorrhea, a well-known Sexually Transmitted Infection (STI) often referred to as “The Gentleman’s Disease,” has a long-standing history and global prevalence.

 

However, scientists from GlaxoSmithKline (GSK) have expressed hope that the disease could soon be eradicated.

 

In recent years, the rise of drug-resistant strains of the bacteria responsible for gonorrhea, known as Neisseria gonorrhoeae, has significantly complicated its treatment with conventional medications.

 

As a result, the disease has become increasingly difficult to cure, nearing a state of near incurability.

 

The issue of antibiotic resistance in the treatment of gonorrhea has raised concerns due to the fact that all bacteria associated with the infection have developed resistance to at least one commonly used antibiotic.

 

Ceftriaxone, an intravenously administered medication, is currently in high demand but also faces increasing resistance.

 

While a legal vaccine for gonorrhea is not currently available, researchers have now set their sights on the potential of an injectable vaccine, which could offer a treatment option.

 

The investigational vaccine has successfully completed phase I studies, demonstrating its safety for human use, and is currently progressing through phase II trials.

 

The anticipated timeline suggests that final testing for the vaccine could commence as early as 2026, potentially opening up a new avenue for combating gonorrhea.

 

The US Food and Drug Administration (FDA) has taken proactive measures to expedite the development of an experimental vaccine aimed at eliminating the threat of gonorrhea.

 

This initiative is expected to accelerate the approval process and facilitate the swift dissemination of the vaccine among the general population.

 

In a comprehensive study, phase II trials involved 750 participants from eight countries, including the US, UK, France, and Spain. These individuals, aged between 18 and 50, were specifically selected due to their higher risk of contracting gonorrhea.

 

The phase II trials commenced in November 2022, and by March 2025, the results of this phase are anticipated to be available. Subsequently, phase III trials will commence, marking another significant step towards the potential availability of the vaccine.

 

Patients receive two doses of the vaccine by injection into the muscle in order to produce immunity. The vaccine’s mechanism of action is unknown, but researchers note that similar vaccines have been created in the past that employ antigens from bacterial surfaces to elicit an immune response.

 

The FDA’s decision to provide our novel vaccine candidate against Neisseria gonorrhoeae illness Fast Track designation is something we applaud, according to Phil Dormitzer, the global head of vaccine development at GSK.

 

The global prevalence of gonorrhea poses a significant threat to sexual and reproductive health worldwide. With its high and increasing incidence, the need for effective prevention measures is paramount.

 

The prospect of a vaccine holds great promise in potentially safeguarding millions of individuals from the severe health consequences associated with this infection caused by a bacterium categorized by the World Health Organization as a “high priority” pathogen.

 

Gonorrhea can easily spread from one person to another through vaginal contact with an infected partner. Additionally, there is a risk of perinatal transmission from mother to baby during childbirth.

 

However, it is worth noting that men face a considerable 20 percent chance of contracting the disease through sexual activity. This emphasizes the importance of safe sexual practices and raises awareness about the risks associated with gonorrhea transmission.

Health

Cholera Outbreak In Sokoto Claims 25 Lives, Over 1,000 Infected

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A cholera outbreak in Sokoto State has claimed the lives of at least 25 people, with 1,160 confirmed cases recorded in three local government areas.

The state Commissioner for Health, Dr. Asabe Balarabe, disclosed this during a press briefing on Monday.

She revealed that 15 patients are currently receiving treatment for the disease, which was confirmed through laboratory tests.

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“Out of 1,160 people affected by the outbreak, 25 have succumbed to the disease,” Dr. Balarabe said.

In response, the state government has ramped up efforts to curtail the spread of the infection, which is caused by consuming contaminated water or food.

“The state rescue teams are collaborating with the government to manage and forestall further spread of the dreaded disease,” the commissioner stated.

To address the crisis, the government has ordered the immediate purchase and distribution of essential drugs free of charge to all 18 local government areas of the state.

Dr. Balarabe urged residents to maintain proper hygiene and seek medical attention immediately if they exhibit symptoms such as diarrhea and vomiting.

The outbreak has highlighted the need for improved sanitation and clean water access in affected communities, as health authorities work to contain the spread and prevent further fatalities.

 

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Health

Don’t Ignore These Hidden Health Clues In Your Urine

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Your body has subtle ways of communicating essential information about your health—and sometimes, one of the simplest clues is the color of your urine.

Urine, which is about 95% water, forms when your kidneys filter out waste and excess water from your blood. Normally ranging from light yellow to amber, it provides insights into your hydration and more.

Changes in urine color, smell, or frequency can serve as early indicators of potential health conditions.

While most color shifts are harmless and temporary, persistent changes could suggest a more significant issue.

“Tracking these signs can be a simple way to monitor hydration and potentially catch health issues early,” says Dr. Jenna Lewis, a nephrologist at Healthline Clinic.

Here’s a guide to what different urine colors might mean for your health:

Clear or Very Light Yellow

This typically shows you’re well-hydrated. While generally a positive sign, consistently clear urine could indicate overhydration, which may lower salt levels in your body.

Light to Medium Yellow

Often considered the “healthy” zone, this shade reflects good hydration without excess water intake.

Dark Yellow to Amber

A darker shade often indicates a need for more water. This is common in the morning or after exercise and can usually be resolved by drinking more fluids.

Orange

Dehydration may lead to orange urine, but other factors can also contribute. High levels of beta-carotene (found in foods like carrots) or certain medications can turn urine orange.

Persistent orange urine might signal liver or bile duct issues, so consult a doctor if it persists.

Pink or Red

While foods like beets or berries can cause pinkish urine, this color can also indicate the presence of blood, possibly signaling kidney problems, infections, or kidney stones. If diet isn’t the cause, seek medical advice.

Brown or Cola-Colored

This shade may suggest dehydration or, in some cases, a more severe issue. Brown urine can indicate liver or kidney problems, or a condition called rhabdomyolysis, where muscle tissue breaks down. Persistent brown urine warrants a visit to the doctor.

Blue or Green

Rarely, certain medications, dyes, or health conditions can produce blue or green urine. While often harmless, persistent blue or green urine should be evaluated by a healthcare provider.

Cloudy or Milky

Cloudy urine may indicate an infection or excess minerals. It could be a sign of a urinary tract infection, kidney stones, or mild dehydration. Sometimes, excess proteins or fats may also cause this cloudiness.

Most changes in urine color are temporary, especially when related to hydration, diet, or harmless compounds. However, experts agree that if unusual colors or symptoms persist, a consultation with a healthcare provider is wise.

“Listening to your body’s signals, even through something as simple as urine color, can offer valuable insights into your overall health,” adds Dr. Lewis.

By keeping an eye on these colors, you can stay on top of hydration and potentially catch health issues early.

 

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Health

JUST IN: JOHESU Launches Nationwide Strike Over Unresolved Demands

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Members of the Joint Health Sector Unions and Assembly of Health Care Professionals (JOHESU) have announced a seven-day warning strike set to begin at midnight on Friday.

This action follows a 15-day notice of industrial action issued to the Federal Government.

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Addressing journalists in Abuja, JOHESU’s national chairman, Kabiru Minjibir, outlined the union’s primary demands, emphasizing a need for immediate action to address ongoing concerns affecting healthcare workers across the nation.

Key demands include the urgent implementation of the consolidated health salary structure and the payment of a 25 percent review of arrears from June to December 2023.

The union is also calling for an upward review of the retirement age for healthcare workers, a tax waiver on healthcare workers’ allowances, and the immediate disbursement of COVID-19 inducement hazard allowances.

Minjibir urged all union members nationwide to adhere to the strike directive, underscoring that compliance would be essential in pushing for their demands.

 

 

 

 

Details shortly…………. 

 

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